Sinc-based convolutional neural networks for EEG-BCI-based motor imagery classification

Brain-Computer Interfaces (BCI) based on motor imagery translate mental motor images recognized from the electroencephalogram (EEG) to control commands. EEG patterns of different imagination tasks, e.g. hand and foot movements, are effectively classified with machine learning techniques using band power features. Recently, also Convolutional Neural Networks (CNNs) that learn both effective features and classifiers simultaneously from raw EEG data have been applied. However, CNNs have two major drawbacks: (i) they have a very large number of parameters, which thus requires a very large number of training examples; and (ii) they are not designed to explicitly learn features in the frequency domain. To overcome these limitations, in this work we introduce Sinc-EEGNet, a lightweight CNN architecture that combines learnable band-pass and depthwise convolutional filters. Experimental results obtained on the publicly available BCI Competition IV Dataset 2a show that our approach outperforms reference methods in terms of classification accuracy

COVID-19, AIR POLLUTION AND MENTAL ILLNESS: HEADS OF THE SAME "BEAST"?

The Covid-19 outbreak are generating relevant consequences under several aspects. Covid-19 pandemic together with air pollution and a dysfunctional anthropization/urbanization might affect public and mental health with a synergistic effect. The current paper explore hypothesis about existing links among Covid-19, air pollution and mental illness

COVID-19, AIR POLLUTION AND MENTAL ILLNESS: HEADS OF THE SAME "BEAST"?

The Covid-19 outbreak are generating relevant consequences under several aspects. Covid-19 pandemic together with air pollution and a dysfunctional anthropization/urbanization might affect public and mental health with a synergistic effect. The current paper explore hypothesis about existing links among Covid-19, air pollution and mental illness

Darkside: A Heterogeneous RISC-V Compute Cluster for Extreme-Edge On-Chip DNN Inference and Training

On-chip DNN inference and training at the Extreme-Edge (TinyML) impose strict latency, throughput, accuracy and flexibility requirements. Heterogeneous clusters are promising solutions to meet the challenge, combining the flexibility of DSP-enhanced cores with the performance and energy boost of dedicated accelerators. We present Darkside, a System-on-Chip with a heterogeneous cluster of 8 RISC-V cores enhanced with 2-b to 32-b mixed-precision integer arithmetic. To boost performance and efficiency on key compute-intensive Deep Neural Network (DNN) kernels, the cluster is enriched with three digital accelerators: a specialized engine for low-data-reuse depthwise convolution kernels (up to 30 MAC/cycle); a minimal overhead datamover to marshal 1-b to 32-b data on-the-fly; a 16-b floating point Tensor Product Engine (TPE) for tiled matrix-multiplication acceleration. Darkside is implemented in 65nm CMOS technology. The cluster achieves a peak integer performance of 65 GOPS and a peak efficiency of 835 GOPS/W when working on 2-b integer DNN kernels. When targeting floating-point tensor operations, the TPE provides up to 18.2 GFLOPS of performance or 300 GFLOPS/W of efficiency – enough to enable on-chip floating-point training at competitive speed coupled with ultra-low power quantized inference

CORRELATES OF INVOLUNTARY ADMISSION: FINDINGS FROM AN ITALIAN INPATIENT PSYCHIATRIC UNIT

Background: Involuntary admission is challenging in terms of providing the most effective but least restrictive care in accordance with the country’s regulations. A better understanding of correlates of voluntary versus involuntary admission legal status is crucial to improve clinical decision-making and effectiveness of the overall mental health care system. Subjects and methods: We collected chart-review data pertaining to 848 patients, discharged between June 2011 and June 2014, from an Italian inpatient psychiatric unit. Diverse sociodemographic and clinical variables were collected. Bivariate analyses and binary logistic regression were performed to examine correlates of involuntary admission. Results: Bivariate analyses showed that involuntary status was related to: the reason for hospitalization, not being on psychiatric medications at admission, and being admitted from another inpatient ward (in particular, from the emergency department). The final regression model identified four main variables independently associated with legal status: being admitted for psychotic features, suicidal behavior, or impulsive behavior, and not being on medication at admission (Nagelkerke pseudo R2=0.15, p<0.001). A strong association with length of stay was also documented. Conclusions: Understanding the causes and consequences of involuntary admission will enhance the field’s understanding of how to provide the most effective, but least restrictive, psychiatric care

Evaluation of Ki-67 expression in feline non-ocular melanocytic tumours

Fifty tumours located in skin (n = 33) and mucosae (n = 17) were included. Forty-eight percent and 95% of amelanotic tumours (n = 21) stained positive for Melan A and S100, respectively. Most achromic tumours were mucosal (P  5, Ki-67 > 20% and lack of treatment administration. On multivariable analysis, only tumour histotype and treatment retained prognostic significance. Conclusions Although the majority of feline NOMs behave aggressively, Ki-67 index, together with other parameters, may contribute to prognostic assessment. Prospective studies on homogeneous populations are warranted to identify reliable threshold values for this marker

Early diagnosis of bladder cancer by photoacoustic imaging of tumor-targeted gold nanorods

Detection and removal of bladder cancer lesions at an early stage is crucial for preventing tumor relapse and progression. This study aimed to develop a new technological platform for the visualization of small and flat urothelial lesions of high-grade bladder carcinoma in situ (CIS). We found that the integrin alpha 581, overexpressed in bladder cancer cell lines, murine orthotopic bladder cancer and human bladder CIS, can be exploited as a receptor for targeted delivery of GNRs functionalized with the cyclic CphgisoDGRG peptide (Iso4). The GNRs@Chit-Iso4 was stable in urine and selectively recognized alpha 581 positive neoplastic urothelium, while low frequency ultrasound-assisted shaking of intravesically instilled GNRs@Chit-Iso4 allowed the distribution of nanoparticles across the entire volume of the bladder. Photoacoustic imaging of GNRs@Chit-Iso4 bound to tumor cells allowed for the detection of neoplastic lesions smaller than 0.5 mm that were undetectable by ultrasound imaging and bioluminescence

The effects of psychoeducational family intervention on coping strategies of relatives of patients with bipolar i disorder: Results from a controlled, real-world, multicentric study

Background: Psychoeducational family intervention (PFI) has been proven to be effective in improving the levels of family burden and patients\u2019 personal functioning in schizophrenia and bipolar disorders (BDs). Less is known about the impact of PFI on relatives\u2019 coping strategies in BD. Methods: A multicenter, controlled, outpatient trial funded by the Italian Ministry of Health and coordinated by the Department of Psychiatry of the University of Campania \u201cLuigi Vanvitelli\u201d has been conducted in patients with bipolar I disorder (BD-I) and their key relatives consecutively recruited in 11 randomly selected Italian community mental health centers. We aim to test the hypothesis that PFI improves problem-oriented coping strategies in relatives of BD-I patients compared to the Treatment As Usual (TAU) group. Results: The final sample was constituted of 123 patients and 139 relatives. At baseline assessment (T0), the vast majority of relatives already adopted problem-oriented coping strategies more frequently than the emotion-focused ones. At the end of the intervention, relatives receiving PFI reported a higher endorsement of adaptive coping strategies, such as \u201cmaintenance of social interests\u201d (odds ratio [OR]=0.309, CI=0.04\u20130.57; p=0.023), \u201cpositive communication with the patient\u201d (OR=0.295, CI=0.13\u20130.46; p=0.001), and \u201csearching for information\u201d (OR=0.443, CI=0.12\u20130.76; p=0.007), compared to TAU relatives, after controlling for several confounders. As regards the emotion-focused coping strategies, relatives receiving the experimental intervention less frequently reported to adopt \u201cresignation\u201d (OR=-0.380, CI=-0.68 to -0.08; p=0.014) and \u201ccoercion\u201d (OR=-0.268, CI=-0.46 to -0.08; p=0.006) strategies, compared to TAU relatives. Conclusion: PFI is effective in improving the adaptive coping strategies of relatives of BD-I patients, but further studies are needed for evaluating the long-term benefits of this intervention

Randomised controlled trial combining vitamin E-functionalised chocolate with physical exercise to reduce the risk of protein-energy malnutrition in predementia aged people: study protocol for Choko-Age

Objective: Protein-energy malnutrition and the subsequent muscle wasting (sarcopenia) are common ageing complications. It is knowing to be also associated with dementia. Our programme will test the cytoprotective functions of vitamin E combined with the cortisol-lowering effect of chocolate polyphenols (PP), in combination with muscle anabolic effect of adequate dietary protein intake and physical exercise to prevent the age-dependent decline of muscle mass and its key underpinning mechanisms including mitochondrial function, and nutrient metabolism in muscle in the elderly. Methods and analysis: In 2020, a 6-month double-blind randomised controlled trial in 75 predementia older people was launched to prevent muscle mass loss, in respond to the 'Joint Programming Initiative A healthy diet for a healthy life'. In the run-in phase, participants will be stabilised on a protein-rich diet (0.9-1.0 g protein/kg ideal body weight/day) and physical exercise programme (high-intensity interval training specifically developed for these subjects). Subsequently, they will be randomised into three groups (1:1:1). The study arms will have a similar isocaloric diet and follow a similar physical exercise programme. Control group (n=25) will maintain the baseline diet; intervention groups will consume either 30 g/day of dark chocolate containing 500 mg total PP (corresponding to 60 mg epicatechin) and 100 mg vitamin E (as RRR-alpha-tocopherol) (n=25); or the high polyphenol chocolate without additional vitamin E (n=25). Muscle mass will be the primary endpoint. Other outcomes are neurocognitive status and previously identified biomolecular indices of frailty in predementia patients. Muscle biopsies will be collected to assess myocyte contraction and mitochondrial metabolism. Blood and plasma samples will be analysed for laboratory endpoints including nutrition metabolism and omics. Ethics and dissemination: All the ethical and regulatory approvals have been obtained by the ethical committees of the Azienda Ospedaliera Universitaria Integrata of Verona with respect to scientific content and compliance with applicable research and human subjects' regulation. Given the broader interest of the society toward undernutrition in the elderly, we identify four main target audiences for our research activity: national and local health systems, both internal and external to the project; targeted population (the elderly); general public; and academia. These activities include scientific workshops, public health awareness campaigns, project dedicated website and publication is scientific peer-review journals. Trial registration number: NCT05343611

Salerno Quadrante. N.1-3 (1955)

1 (giugno 1955): Guglielmo Longo, Ospedali, esigenza prima del Mezzo giorno, P. 3 ; Giuseppe Lanocita, Attualità della questione demaniale e suoi aspetti nel comune di Eboli, P. 9 ; Bilancio di un disastro: L'alluvione in cifre, P. 11 ; Alessandro Pinto, Canti popolari cilentani, P. 17 ; Giovanni Capasso, Poesie inedite, P. 18 ; Francesco Franco. S. Pietro al Tanagro, il paese dalle tovaglie di terra, P. 19 ; Antonio De Angelis, Scafati, cittadina di provincia, P. 23 ; Enzo Barba, Matteo Luciani, P. 25 ; Augusto Visconti, Curiosità e irrequietezza in tre giovani pittori salernitani: D'Agosto, Gentile, Della Monica, P. 28 ; II Centro di cultura Citta di Salerno, P. 29 ; Recensioni, P. 32- 40 ; La resistenza salernitana (fuori testo).2-3 (dicembre 1955): Ugo Renna, Viaggio nel Cilento, P. 3 ; Francesco Franco, La crisi tessile e Ie M.C.M. Fratte-Pellezzano, P. 14 ; Giuseppe Tortorella, II problema del Porto (intervista), P. 23 ; Guglielmo Longo, Difendiamo l'industria salernitana, P. 27 ; Enzo Barba, Errico de Marinis e il "socialismo demariniano, P. 33 ; Giuseppe Lanocita, Attualità della questione demaniale e suoi aspetti nel comune di Eboli, P. 43 ; Giuseppe A. Leone, Pietà per Crocco il brigante (poesia), p. 52 ; Gianni Nunziante, Titoli di proprietà immobiliare al portatore nella pratica medievale salernitana, P. 53 ; Mario Carotenuto, Olga Napoli nella pittura contemporanea (fuori testo)